🔬 The Bitter Lesson is Coming for Proteins - Alex Rives, BioHub
Jun 1, 2026 · 1:10:12
Alex Rives, head of science at BioHub, argues that scaling laws and the bitter lesson apply to protein biology, as demonstrated by the open-source release of ESM-C and ESMFold 2. He explains how training on billions of metagenomic sequences enabled a world model that designs antibodies and predicts structures without multiple sequence alignments, and outlines BioHub's vision for a virtual cell built on scaled interventional data, spatial biology, and feedback loops.
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